Thursday, September 23, 2010

Back to Free Extra Material to the ebook: "Thoughtful Living"


The ebook can be viewed at: "GOSSYPOL-Potential-Oral-Contraceptive"

BELOW IS AN EXCERPT ONLY:

GOSSYPOL: A Potential Oral Male Contraceptive

By Thomas Blankenhorn


Contents

I. Introduction
II. Occurrence
III. Contraceptive Property Discovery
IV. Clinical Studies
V. Antifertility Effect
VI. Physical Properties
VII. Extraction
VIII. Synthesis
IX. Summary






REFERENCES

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2. Frick, J., Aulitzky, W. “Male contraception.” Human Reproduction 1988; 3:147-151.

3. Steinberger, E., Smith, K.D. “Effect of chronic administration of testosterone enanthate on sperm production and plasma testosterone. FSH and LH levels: a preliminary evaluation of a possible male contraceptive.” Fertility and Sterility 1977; 28: 1320-1328.

4. Marchlewski, L. Journal feur Praktishe Chemie 1899; 60:84.

5. USDA, Foreign Agricultural Service, “Foreign Agriculture Circular.” Food Fats and Oils 1-70, Feb 1970.

6. Vix, H.L.E. et al. “Degossypolized cottonseed flour – The Liquid Cyclone Process.” Journal of the American Oil Chemists’ Society 1971; 48: 611-615.

7. Koltun, S.P., et al. Journal of the American Oil Chemists’ Society 1959; 36: 349.

8. Maugh, T.H. “Male ‘pill’ blocks sperm enzyme.” Science 1981; 212: 314.

9. National Coordinating Group on male Antifertility Agents. “Gossypol – a new antifertility agent for male.” Chinese Medical Journal 1978; 4: 417-428.

10. Liu, G.Z., Lyle, C., Cao, J.A. “Experiences with gossypol as a male pill.” American Journal of Obstetrics and Gynecology 1987; 157: 1079-1081.

11. Meng, G.D. et al. “Follow-up of men in the recovery period immediately after the cessation of gossypol treatment.” Contraception 1988; 37: 119-128.

12. Coutino, E.M. “Clinical experience with gossypol in non-Chinese men: A follow-up.” Contraception 1988; 37: 137-152.

13. Lohiya, N.K., et al. “Limitations in developing gossypol acetic acid as a male contraceptive.” Contraception 1990; 41: 519-532.

14. Qian, S.Z. “Gossypol-hypokalaemia interrelationships.” International Journal of Andrology 1985; 8: 313-324.

15. Porat, O. “Effects of gossypol on the motility of mammalian sperm.” Molecular Reproduction and Development 1990; 25: 400-408.

16. Zhong, C.Q., et al. “Study on sperm function in men long after cessation of gossypol treatment.” Contraception 1990; 41: 617-622.

17. Yu, Y.W. “Probing into the mechanism of action, metabolism and toxicity of gossypol by studying its (+) and (-) stereoisomers.” Journal of Ethnopharmacology 1987; 20: 65-78.

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21. Johnson, W.S., Daub, G.H. Organic Reactions 1951; 6: 1.

22. Edwards, Jr., J.D. Journal of the American Oil Chemists’ Society 1970; 47: 441-442.

23. Edwards, Jr., J.D. “Total synthesis of gossypol.” Journal of the American Oil Chemists’ Society 1958; 80: 3798-3799.

24. Carruth, F.E. Journal of the American Chemical Society 1918; 40: 647.

25. Frick, J., et al. “Clinical microdose study of gossypol: Effect on sperm motility and renal function.” Contraception 1988; 37: 153-162.

26. Poso, H., et al. “Gossypol, a powerful inhibitor of human spermatozoal metabolism.” The Lancet 1980; 1: 885-886.